Article
Interleukin 9: a candidate gene for asthma.
Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997
Nicolaides N C, Holroyd K J, Ewart S L, Eleff S M, Kiser M B, Dragwa C R, Sullivan C D, Grasso L, Zhang L Y, Messler C J, Zhou T, Kleeberger S R, Buetow K H, Levitt R C
Abstract excerpt
Asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of atopy and bronchial hyperresponsiveness. Recent studies localized a major gene for asthma to chromosome 5q31-q33 in humans. Thus, this segment of the genome represents a candidate region for genes that determine susceptibility to bronchial hyperresponsiveness and atopy in animal models. Homologs of candidate genes...
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