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Article

Mouse Keratin 4 Is Necessary for Internal Epithelial Integrity

1 Sept 1998

Abstract excerpt

Keratins are intermediate filaments of epithelial cells. Mutations in keratin genes expressed in skin lead to human disorders, including epidermolysis bullosa simplex and epidermolytic hyperkeratosis. We examined the role of keratin 4 (K4) in maintaining the integrity of internal epithelial linings by using gene targeting to generate mice containing a null mutation in the epithelial K4 gene. Homozygous mice that...

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Identifiers

PMID: 9727004
DOI: 10.1074/jbc.273.37.23904

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