Article
A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence.
Alcoholism, clinical and experimental research - 1 Aug 1998
Edenberg H J, Reynolds J, Koller D L, Begleiter H, Bucholz K K, Conneally P M, Crowe R, Goate A, Hesselbrock V, Li T K, Nurnberger J I, Porjesz B, Reich T, Rice J P, Schuckit M, Tischfield J A, Foroud T
Abstract excerpt
A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families...
Topics
- Adult
- Aged
- Alcohol Withdrawal Delirium
- Alcoholism
- Alleles
- Carrier Proteins
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans
- Linkage Disequilibrium