Diverse essential functions revealed by complementing yeast calmodulin mutants.

doi:10.1126/science.8310294

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Article

Diverse essential functions revealed by complementing yeast calmodulin mutants.

Science (New York, N.Y.) - 18 Feb 1994

Ohya Y, Botstein D

Abstract excerpt

Calmodulin, a cytoplasmic calcium-binding protein, is indispensable for eukaryotic cell growth. Examination of 14 temperature-sensitive yeast mutants bearing one or more phenylalanine to alanine substitutions in the single essential calmodulin gene of yeast (CMD1) revealed diverse essential funct...

Topics

Actins
Calmodulin
Cell Cycle
DNA Replication
Genes, Fungal
Genetic Complementation Test
Mutagenesis, Site-Directed
Mutation
Phenotype
Saccharomyces cerevisiae
Temperature

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