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Article

Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.

Molecular & general genetics : MGG - 1 Mar 1999

Hemenway C S, Heitman J

Abstract excerpt

The target of the immunosuppressants cyclosporin A(CsA) and FK506 is calcineurin, a highly conserved protein phosphatase that is required for T-cell activation and the regulation of ion homeostasis in yeast. Here we identify two genes, PMR2B and LIC4 which, when overexpressed, suppress the cation-sensitive phenotype of yeast cells lacking calcineurin. PMR2B encodes a Na+/Li+-specific plasma membrane pump and is...

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Identifiers

PMID: 10102375
DOI: 10.1007/s004380050980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.PMID 10102375Read ↗

Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1.Semantic proximity Read ↗

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.Semantic proximity Read ↗

Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase.Semantic proximity Read ↗

Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin.Semantic proximity Read ↗

ARL1 participates with ATC1/LIC4 to regulate responses of yeast cells to ions.Semantic proximity Read ↗

A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter.Semantic proximity Read ↗

Identification of a calcineurin-independent pathway required for sodium ion stress response in Saccharomyces cerevisiae.Semantic proximity Read ↗

pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast.Semantic proximity Read ↗

The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Adaptation to high-salt stress in Saccharomyces cerevisiae is regulated by Ca2+/calmodulin-dependent phosphoprotein phosphatase (calcineurin) and cAMP-dependent protein kinase.Semantic proximity Read ↗

Mutual antagonism of target of rapamycin and calcineurin signaling.Semantic proximity Read ↗

The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.Semantic proximity Read ↗

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