Article
Disabling of the erbB Pathway Followed by IFN-γ Modifies Phenotype and Enhances Genotoxic Eradication of Breast Tumors.
Cell reports - 29 Sept 2015
Nagai Yasuhiro, Tsuchiya Hiromichi, Runkle E Aaron, Young Peter D, Ji Mei Q, Norton Larry, Drebin Jeffrey A, Zhang Hongtao, Greene Mark I
Abstract excerpt
Reversion of the malignant phenotype of erbB2-transformed cells can be driven by anti-erbB2/neu monoclonal antibodies (mAbs), which disrupt the receptor's kinase activity. We examined the biologic effects of IFN-γ alone or after anti-erbB2/neu mAb treatment of erbB2-positive cells. IFN-γ had no effect on its own. Treatment of the tumors with anti-erbB2/neu mAbs followed by IFN-γ led to dramatic inhibition of...
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