GABA induces terminal differentiation of Dictyostelium through a GABAB receptor.

doi:10.1242/dev.02399

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Article

GABA induces terminal differentiation of Dictyostelium through a GABAB receptor.

Development (Cambridge, England) - 1 Jun 2006

Anjard Christophe, Loomis William F

Abstract excerpt

When prespore cells approach the top of the stalk in a Dictyostelium fruiting body, they rapidly encapsulate in response to the signalling peptide SDF-2. Glutamate decarboxylase, the product of the gadA gene, generates GABA from glutamate. gadA is expressed exclusively in prespore cells late in development. We have found that GABA induces the release of the precursor of SDF-2, AcbA, from prespore cells. GABA also...

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PMID: 16672332
DOI: 10.1242/dev.02399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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