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Article

How HLA diversity is apportioned: influence of selection and relevance to transplantation.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 6 Jun 2022

Maróstica André Silva, Nunes Kelly, Castelli Erick C, Silva Nayane S B, Weir Bruce S, Goudet Jérôme, Meyer Diogo

Abstract excerpt

In his 1972 paper 'The apportionment of human diversity', Lewontin showed that, when averaged over loci, genetic diversity is predominantly attributable to differences among individuals within populations. However, selection can alter the apportionment of diversity of specific genes or genomic regions. We examine genetic diversity at the human leucocyte antigen (HLA) loci, located within the major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35430892
DOI: 10.1098/rstb.2020.0420
PMCID: PMC9014195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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