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Article

Effect of mutations in Candida antarctica B lipase.

Chemistry and physics of lipids - 1 Jun 1998

Patkar S, Vind J, Kelstrup E, Christensen M W, Svendsen A, Borch K, Kirk O

Abstract excerpt

Three variants of the Candida antarctica B lipase have been constructed and characterized. The variant containing the T103G mutation, which introduces the consensus sequence G-X-S-X-G found in most other known lipases, shows an increased thermostability but retains only half the specific activity of the native enzyme. Also in ester synthesis the activity is lowered but the specificity and enantioselectivity...

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Identifiers

PMID: 9720252
DOI: 10.1016/s0009-3084(98)00032-2

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