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Article

Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome.

Journal of medical genetics - 1 Sept 1996

Froggatt N J, Brassett C, Koch D J, Evans D G, Hodgson S V, Ponder B A, Maher E R

Abstract excerpt

Germline mutations in four human mismatch repair genes (MSH2, MLH1, PMS1, and PMS2) have been reported to cause hereditary non-polyposis colon cancer syndrome (HNPCC). The identification of germline mutations in HNPCC kindreds allows precise diagnosis and accurate predictive testing. To investigate further the genetic epidemiology of HNPCC and the nature and frequency of germline mutations in this disorder, we...

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Source

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Identifiers

PMID: 8880570
DOI: 10.1136/jmg.33.9.726
PMCID: PMC1050724

Genes

MSH2
MLH1
PMS1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome.PMID 8880570Read ↗

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