Article
In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer.
Gastroenterology - 1 Oct 1995
Luce M C, Marra G, Chauhan D P, Laghi L, Carethers J M, Cherian S P, Hawn M, Binnie C G, Kam-Morgan L N, Cayouette M C
Abstract excerpt
BACKGROUND & AIMS: Hereditary nonpolyposis colorectal cancer (HNPCC) has been linked recently to a defect in repairing mismatched nucleotides in DNA. The aim of this study was to screen for germline mutations that result in prematurely truncated proteins in two of the mismatch repair genes identi...
Topics
- Base Sequence
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Genetic Testing
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Biosynthesis
- Transcription, Genetic