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Article

In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer.

Gastroenterology - 1 Oct 1995

Luce M C, Marra G, Chauhan D P, Laghi L, Carethers J M, Cherian S P, Hawn M, Binnie C G, Kam-Morgan L N, Cayouette M C

Abstract excerpt

BACKGROUND & AIMS: Hereditary nonpolyposis colorectal cancer (HNPCC) has been linked recently to a defect in repairing mismatched nucleotides in DNA. The aim of this study was to screen for germline mutations that result in prematurely truncated proteins in two of the mismatch repair genes identified at this time, hMLH1 and hMSH2, in a consecutive series of patients belonging to familial aggregations of...

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Identifiers

PMID: 7557107
DOI: 10.1016/0016-5085(95)90600-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer.PMID 7557107Read ↗

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Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex.Semantic proximity Read ↗

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RNA-based mutation screening in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

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