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Article

Molecular regulation of receptor tyrosine kinases in hematopoietic malignancies.

Gene - 7 Jun 2006

Correll Pamela H, Paulson Robert F, Wei Xin

Abstract excerpt

Dysregulation of receptor tyrosine kinase (RTK) activity has been implicated in the progression of a variety of human leukemias. Most notably, mutations and chromosomal translocations affecting regulation of tyrosine kinase activity in the Kit receptor, the Flt3 receptor, and the PDGFbeta/FGF1 receptors have been demonstrated in mast cell leukemia, acute myeloid leukemia (AML), and chronic myelogenous leukemias...

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Share to Dimerization
Share to Leukemia
Share to Leukemia, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Protein Structure, Secondary

Share to Receptor Protein-Tyrosine Kinases

Share to Translocation, Genetic

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Source

Identifiers

PMID: 16524673
DOI: 10.1016/j.gene.2006.01.023

Genes

FGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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