Article
Papillary renal cell carcinoma: analysis of germline mutations in the MET proto-oncogene in a clinic-based population.
Genetic testing - 1 Jan 2001
Lindor N M, Dechet C B, Greene M H, Jenkins R B, Zincke M T, Weaver A L, Wilson M, Zincke H, Liu W
Abstract excerpt
Approximately 10% of all renal cell carcinomas (RCCs) present a distinctive papillary histology. Familial papillary RCC (PRCC) has been described, but the majority of cases appear to be sporadic. Recently, germline mutations in the MET proto-oncogene on chromosome 7 have been identified in families with hereditary PRCC. We evaluated 59 patients with PRCC for the frequency of MET germline mutations to determine...
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