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Article

Protective Immunity in Macaques Vaccinated with Live Attenuated, Recombinant, and Subunit Measles Vaccines in the Presence of Passively Acquired Antibodies

1 Mar 1997

Abstract excerpt

The presence of maternal antibodies is one of the main causes of measles vaccine failure. To evaluate the interference of passively acquired antibodies with vaccine efficacy, macaques (n = 16) were vaccinated with live attenuated measles vaccine in the presence or absence of passively acquired measles virus-specific monkey serum antibodies. As little as 0.1 IU of virus-neutralizing antibody/mL of serum abrogated...

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PMID: 9041322
DOI: 10.1093/infdis/175.3.524

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