Article
Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.
The Journal of clinical investigation - 1 Jan 2005
Smythies Lesley E, Sellers Marty, Clements Ronald H, Mosteller-Barnum Meg, Meng Gang, Benjamin William H, Orenstein Jan M, Smith Phillip D
Abstract excerpt
Intestinal macrophages, which are thought to orchestrate mucosal inflammatory responses, have received little investigative attention compared with macrophages from other tissues. Here we show that human intestinal macrophages do not express innate response receptors, including the receptors for LPS (CD14), Fcalpha (CD89), Fcgamma (CD64, CD32, CD16), CR3 (CD11b/CD18), and CR4 (CD11c/CD18); the growth factor...
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