Article
Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice.
European journal of immunology - 1 Aug 1998
Schuh K, Kneitz B, Heyer J, Bommhardt U, Jankevics E, Berberich-Siebelt F, Pfeffer K, Müller-Hermelink H K, Schimpl A, Serfling E
Abstract excerpt
NF-ATp and NF-ATc are the most prominent nuclear NF-AT transcription factors in peripheral T lymphocytes. After T cell activation both factors bind to and control the promoters and enhancers of numerous lymphokine and receptor ligand genes. In order to define a specific role for NF-ATp in vivo we...
Topics
- Animals
- Apoptosis
- Base Sequence
- DNA Primers
- DNA-Binding Proteins
- Germinal Center
- Mice
- Mice, Knockout
- NFATC Transcription Factors
- Nuclear Proteins
- Phenotype
- Polymerase Chain Reaction
- Superantigens
- T-Lymphocytes
- Thymus Gland