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Article

Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway.

The EMBO journal - 15 Aug 2003

Hao Shengli, Kurosaki Tomohiro, August Avery

Abstract excerpt

NFAT and SRF are important in the regulation of proliferation and cytokine production in lymphocytes. NFAT activation by the B cell receptor (BCR) occurs via the PLCgamma-Ca(2+)-calcineurin pathway, however how the BCR activates SRF is unclear. We show here that like NFAT, BCR regulation of SRF o...

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Source

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Identifiers

PMID: 12912915
DOI: 10.1093/emboj/cdg401
PMCID: PMC175791

Genes

SRF
BCR
CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12912915-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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