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Article

Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease.

The Journal of biological chemistry - 21 Nov 2003

Kaser Michael, Kambacheld Melanie, Kisters-Woike Brigitte, Langer Thomas

Abstract excerpt

The integrity of the inner membrane of mitochondria is maintained by a membrane-embedded quality control system that ensures the removal of misfolded membrane proteins. Two ATP-dependent AAA proteases with catalytic sites at opposite membrane surfaces are key components of this proteolytic system. Here we describe the identification of a novel conserved metallopeptidase that exerts activities overlapping with the...

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PMID: 12963738
DOI: 10.1074/jbc.M305584200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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