Article
Dominance of the E89G substitution in HIV-1 reverse transcriptase in regard to increased polymerase processivity and patterns of pausing.
The Journal of biological chemistry - 21 Aug 1998
Quan Y, Inouye P, Liang C, Rong L, Götte M, Wainberg M A
Abstract excerpt
The substitution of a glycine for glutamic acid at position 89 in human immunodeficiency virus-1 (HIV-1) reverse transcriptase (RT) (E89G) confers resistance to several nucleoside and non-nucleoside inhibitors of RT. As residue 89 contacts the template strand, it has been suggested that this muta...
Topics
- Amino Acid Substitution
- Base Sequence
- Cloning, Molecular
- DNA Replication
- Drug Resistance, Microbial
- Escherichia coli
- Glutamic Acid
- Glycine
- HIV Reverse Transcriptase
- HIV-1
- Kinetics
- Molecular Sequence Data
- Mutation
- Protein Processing, Post-Translational
- RNA, Viral
- Recombinant Proteins
- Reverse Transcriptase Inhibitors
- Templates, Genetic