Article
The influence of 3TC-resistance mutations E89G and M184V in the human immunodeficiency virus reverse transcriptase on mispair extension efficiency.
Nucleic acids research - 1 Oct 1998
Hamburgh M E, Drosopoulos W C, Prasad V R
Abstract excerpt
Two nucleoside analog resistance mutations in HIV-1 reverse transcriptase (RT), E89G and M184V, were previously shown to increase the dNTP insertion fidelity of HIV-1 RT. However, forward mutation assays using a lacZ alpha reporter gene have revealed a lack of impact on the overall error rate of...
Topics
- Anti-HIV Agents
- Base Sequence
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- Humans
- Lamivudine
- Molecular Sequence Data
- Mutation
- Reverse Transcriptase Inhibitors