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Article

Evidence indicating that the extracellular loops of the mouse MC5 receptor do not participate in ligand binding.

Molecular and cellular endocrinology - 30 Apr 1998

Schiöth H B, Fredriksson A, Carlsson C, Yook P, Muceniece R, Wikberg J E

Abstract excerpt

The mMC5 receptor was cloned from a genomic library, mutated in the extracellular loops (EL's), expressed and tested for binding to melanocyte stimulating hormone (MSH) peptides. The EL's show low amino acid homology within the MC receptor family. Two mutants of the mMC5 receptor were created in...

Topics

Amino Acid Sequence
Animals
COS Cells
Cloning, Molecular
Humans
Kinetics
Ligands
Melanocyte-Stimulating Hormones
Mice
Molecular Sequence Data
Mutation
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Corticotropin

Receptors, Melanocortin

Sequence Homology, Amino Acid

Source

Identifiers

PMID: 9705079
DOI: 10.1016/s0303-7207(98)00067-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9705079-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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