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Article

Evidence indicating that the extracellular loops of the mouse MC5 receptor do not participate in ligand binding.

Molecular and cellular endocrinology - 30 Apr 1998

Schiöth H B, Fredriksson A, Carlsson C, Yook P, Muceniece R, Wikberg J E

Abstract excerpt

The mMC5 receptor was cloned from a genomic library, mutated in the extracellular loops (EL's), expressed and tested for binding to melanocyte stimulating hormone (MSH) peptides. The EL's show low amino acid homology within the MC receptor family. Two mutants of the mMC5 receptor were created in order to investigate the participation of these regions in ligand binding. The EL1 and EL3 were separately altered by...

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Identifiers

PMID: 9705079
DOI: 10.1016/s0303-7207(98)00067-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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