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Article

APOE-induced microglial activation: an in vitro assay to screen sera from Alzheimer's disease patients and novel therapeutic compounds.

Methods and findings in experimental and clinical pharmacology - 1 Jun 1998

Lombardi V R, García M, Cacabelow R

Abstract excerpt

Recent advances in molecular genetics have suggested that genetic predisposition can be considered one of the most important risk factors for Alzheimer's disease (AD) development. A significant increase in the number of amyloid plaques in AD patients with an apolipoprotein E4 (APOE) allele has be...

Topics

Adult
Aged
Aged, 80 and over
Alzheimer Disease
Animals
Apolipoprotein E4
Apolipoproteins E
Cell Division
Cells, Cultured
Genotype
Humans
Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Rats

Rats, Sprague-Dawley

Source

Identifiers

PMID: 9701775
DOI: 10.1358/mf.1998.20.5.485697

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9701775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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