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Article

The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1.

The Journal of cell biology - 10 Aug 1998

Serini G, Bochaton-Piallat M L, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G

Abstract excerpt

Transforming growth factor-beta1 (TGFbeta1), a major promoter of myofibroblast differentiation, induces alpha-smooth muscle (sn) actin, modulates the expression of adhesive receptors, and enhances the synthesis of extracellular matrix (ECM) molecules including ED-A fibronectin (FN), an isoform de novo expressed during wound healing and fibrotic changes. We report here that ED-A FN deposition precedes alpha-SM...

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Identifiers

PMID: 9700173
DOI: 10.1083/jcb.142.3.873
PMCID: PMC2148176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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