Article
The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype.
Biomaterials - 1 Sept 2009
Beamish Jeffrey A, Fu Alexander Y, Choi Ae-jin, Haq Nada A, Kottke-Marchant Kandice, Marchant Roger E
Abstract excerpt
This study reports on the ability of poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds with pendant integrin-binding GRGDSP peptides (RGD-gels) to support the re-differentiation of cultured vascular smooth muscle cells (SMCs) toward a contractile phenotype. Human coronary artery SMCs were seeded on RGD-gels, hydrogels with other extracellular matrix derived peptides, fibronectin (FN) and laminin (LN)....
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