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Article

The α4β1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2015

Shinde Arti V, Kelsh Rhiannon, Peters John H, Sekiguchi Kiyotoshi, Van De Water Livingston, McKeown-Longo Paula J

Abstract excerpt

Prompt deposition of fibronectin-rich extracellular matrix is a critical feature of normal development and the host-response to injury. Fibronectin isoforms that include the EDA and EDB domains are prominent in these fibronectin matrices. We now report using human dermal fibroblast cultures that the EDA domain of fibronectin or EDA-derived peptides modeled after the C-C' loop promote stress fiber formation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25433338
DOI: 10.1016/j.matbio.2014.11.004
PMCID: PMC4657864

Genes

EDA

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