Article

Tissue growth factor β stimulates fibroblast-like synovial cells to produce extra domain A fibronectin in osteoarthritis

2018-05-31

Abstract excerpt

<h4>Introduction</h4> The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation and tissue repair responses, including tissue growth factor beta (TGFβ)-induced myofibroblast production of extracellular matrix (ECM). Fibronectins are an essential part of the ECM, and injection of fibronectin fragments into rabbit joints is a...

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Literature Corpus work: bd739547-44cd-5eca-a2db-850df543a950
DOI: 10.1101/335562

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