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Article

ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals.

Atherosclerosis - 1 Jul 1998

Gardemann A, Fink M, Stricker J, Nguyen Q D, Humme J, Katz N, Tillmanns H, Hehrlein F W, Rau M, Haberbosch W

Abstract excerpt

BACKGROUND: Presence of the D allele or homozygosity for the deletion (D) allele of the ACE insertion/deletion (I/D) polymorphism has been discussed as potent risk factor for coronary artery disease (CAD) and myocardial infarction (MI). METHODS AND RESULTS: In 2267 male Caucasians the relation of the ACE I/D gene polymorphism to CAD and MI were investigated. An association of the D allele to CAD was detected in...

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Source

Identifiers

PMID: 9699903
DOI: 10.1016/s0021-9150(98)00040-9

Genes

ACE
CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals.PMID 9699903Read ↗

Hypothesis: an angiotensin converting enzyme genotype, present in one in three caucasians, is associated with increased mortality rate.Semantic proximity Read ↗

The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease.Semantic proximity Read ↗

ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals. A case-referent and retrospective cohort study based on the Copenhagen City Heart Study.Semantic proximity Read ↗

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease.Semantic proximity Read ↗

Angiotensin-converting enzyme insertion/deletion polymorphism and risk of myocardial infarction in an updated meta-analysis based on 34993 participants.Semantic proximity Read ↗

Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism and myocardial infarction at very young ages.Semantic proximity Read ↗

Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene.Semantic proximity Read ↗

The angiotensin‐converting enzyme (ACE) genetic polymorphism: its relationship with plasma ACE level and myocardial infarctionSemantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism and premature coronary heart disease.Semantic proximity Read ↗

The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease.Semantic proximity Read ↗

Exclusion of the ACE D/I gene polymorphism as a determinant of endothelial dysfunction.Semantic proximity Read ↗

Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans.Semantic proximity Read ↗

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