Article
Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene.
The Journal of investigative dermatology - 1 Aug 1998
Ichii-Jones F, Lear J T, Heagerty A H, Smith A G, Hutchinson P E, Osborne J, Bowers B, Jones P W, Davies E, Ollier W E, Thomson W, Yengi L, Bath J, Fryer A A, Strange R C
Abstract excerpt
Allelic variation at the melanocyte stimulating hormone receptor (MC1R) gene has been linked with sun-sensitive skin types, suggesting it is a susceptibility candidate for melanoma. We determined the frequency of the val92met, asp294his, and asp84glu MC1R alleles in 190 Caucasian controls and 306 melanoma cases and studied their association with skin type and hair color. The percentage of controls with at least...
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