Induced phenotype targeted therapy: radiation-induced apoptosis-targeted chemotherapy.

doi:10.1093/jnci/dju403

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Article

Induced phenotype targeted therapy: radiation-induced apoptosis-targeted chemotherapy.

Journal of the National Cancer Institute - 1 Feb 2015

Lee Beom Suk, Cho Yong Woo, Kim Gui Chul, Lee Do Hee, Kim Chang Jin, Kil Hee Seup, Chi Dae Yoon, Byun Youngro, Yuk Soon Hong, Kim Kwangmeyung, Kim In-San, Kwon Ick Chan, Kim Sang Yoon

Abstract excerpt

BACKGROUND: Tumor heterogeneity and evolutionary complexity may underlie treatment failure in spite of the development of many targeted agents. We suggest a novel strategy termed induced phenotype targeted therapy (IPTT) to simplify complicated targets because of tumor heterogeneity and overcome tumor evolutionary complexity. METHODS: We designed a caspase-3 specific activatable prodrug, DEVD-S-DOX, containing...

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PMID: 25505252
DOI: 10.1093/jnci/dju403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.