Article
Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 1998
Gilmore E C, Ohshima T, Goffinet A M, Kulkarni A B, Herrup K
Abstract excerpt
The cerebral cortex of mice with a targeted disruption in the gene for cyclin-dependent kinase 5 (cdk5) is abnormal in its structure. Bromodeoxyuridine labeling reveals that the normal inside-out neurogenic gradient is inverted in the mutants; earlier born neurons are most often found superficial...
Topics
- Animals
- Bromodeoxyuridine
- Cell Adhesion Molecules, Neuronal
- Cerebral Cortex
- Chondroitin Sulfates
- Cyclin-Dependent Kinase 5
- Cyclin-Dependent Kinases
- Embryo, Mammalian
- Embryonic and Fetal Development
- Extracellular Matrix Proteins
- Female
- Mice
- Mutation
- Nerve Tissue Proteins
- Neural Pathways
- Pregnancy
- Protein Serine-Threonine Kinases
- Reelin Protein