Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage.

doi:10.1128/JVI.72.9.7494-7500.1998

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Article

Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage.

Journal of virology - 1 Sept 1998

Valli P J, Lukashov V V, Heeney J L, Goudsmit J

Abstract excerpt

During six blood passages of simian immunodeficiency virus SIVsm in rhesus macaques, the asymptomatic period shortened from 18 months to 1 month. To study SIVsm envelope gene (env) evolution during passage in rhesus macaques, the C1 to CD4 binding regions of multiple clones were sequenced at sero...

Topics

Animals
Genes, env
Genetic Variation
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Time Factors

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