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Article

An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003

Kai Toshie, Spradling Allan

Abstract excerpt

Stem cells are thought to reside in regulatory microenvironments ("niches") generated by stable stromal neighbors. To investigate the significance of empty niches vacated by stem cell loss, we studied Drosophila ovarioles, which maintain two to three germ-line stem cells in a niche requiring adhesive stromal cap cells and Decapentaplegic signals. After experimentally emptying the germ-line stem cell niche, cap...

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Identifiers

PMID: 12676994
DOI: 10.1073/pnas.0830856100
PMCID: PMC153607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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