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Article

Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer pathogenesis.

International journal of cancer - 1 Jun 2017

Das Ghosh Damayanti, Mukhopadhyay Indranil, Bhattacharya Amrapali, Roy Chowdhury Rahul, Mandal Nidhu Ranjan, Roy Sudipta, Sengupta Sharmila

Abstract excerpt

In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16-related CaCx, we determined the alleles by reconstructing SNP-based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA-A, HLA-B and HLA-C. We also determined the impact of SNPs and transcriptional alterations of the genes on CaCx. A high density of SNPs was identified from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28268260
DOI: 10.1002/ijc.30681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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