Article
Tetraploid embryos rescue embryonic lethality caused by an additional maternally inherited X chromosome in the mouse.
Development (Cambridge, England) - 1 Sept 1998
Goto Y, Takagi N
Abstract excerpt
Mouse embryos with an additional maternally inherited X chromosome, i.e., disomic for XM (DsXM), cease to grow early in development and have a deficient extraembryonic region. We hypothesized that the underdeveloped extraembryonic region is attributed to two copies of XM that escape inactivation...
Topics
- Aneuploidy
- Animals
- Chimera
- Congenital Abnormalities
- Dosage Compensation, Genetic
- Embryonic and Fetal Development
- Female
- Fetal Death
- Genomic Imprinting
- Gestational Age
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Phenotype
- Polyploidy
- Pregnancy
- Translocation, Genetic