Article
Mutational analysis of the potential phosphorylation sites for protein kinase C on the CCK(A) receptor.
British journal of pharmacology - 1 Jul 1998
Smeets R L, Fouraux M A, Pouwels W, van Emst-de Vries S E, Ronken E, De Pont J J, Willems P H
Abstract excerpt
1. Many G protein-coupled receptors contain potential phosphorylation sites for protein kinase C (PKC), the exact role of which is poorly understood. In the present study, a mutant cholecystokininA (CCK(A)) receptor was generated in which the four consensus sites for PKC action were changed in an alanine. Both the wild-type (CCK(A)WT) and mutant (CCK(A)MT) receptor were stably expressed in Chinese hamster ovary...
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