Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells.

doi:10.1038/sj.onc.1202156

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Article

Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells.

Oncogene - 2 Jul 1998

Fenstermaker R A, Ciesielski M J, Castiglia G J

Abstract excerpt

Amplification and rearrangement of the epidermal growth factor receptor (EGFR) gene occur frequently in malignant gliomas. Rearrangement may also lead to the expression of potentially oncogenic EGFR deletion mutants. Data presented here indicate the existence of a 190 kDa mutant form of the EGFR...

Topics

Antigens, Neoplasm
DNA Primers
DNA, Complementary
ErbB Receptors
Gene Rearrangement
Glioma
Humans
Introns
Multigene Family
Mutation
Polymerase Chain Reaction
RNA, Messenger
RNA, Neoplasm
Sequence Analysis, DNA

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