Article
Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese.
Medical science monitor : international medical journal of experimental and clinical research - 1 Jan 2002
Soma Masayoshi, Nakayama Kiyokazu, Rahmutula Dolkun, Uwabo Jiro, Sato Mikano, Kunimoto Masako, Aoi Noriko, Kosuge Kotoko, Kanmatsuse Katsuo
Abstract excerpt
BACKGROUND: The Dopamine D3 receptor (DRD3) gene is thought to be involved in essential hypertension (EH) because dopamine inhibits renin secretion via this receptor and because disruption of the DRD3 gene increases blood pressure in mice. EH is a complex, polygenetic disease. Association studies using the candidate gene approach may provide important clues regarding the etiology of hypertension and define a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
