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Article

NBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiation.

Journal of neurochemistry - 1 Jul 2007

Lee Wang-Tso, Chang Wen-Hsin, Huang Chi-Hung, Wu Kou-Juey

Abstract excerpt

Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder, characterized by progressive microcephaly, growth retardation, immunodeficiency, and pre-disposition to tumor formation. To investigate the functions of the NBS gene product, NBS1, on neurons, PC12 cells overexpressing NBS1 and related mutants and primary cortical neuronal culture were used in the present study. Small interfering RNA (siRNA) was...

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Identifiers

PMID: 17442057
DOI: 10.1111/j.1471-4159.2007.04477.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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