Molecular cloning of the hamster CMP-sialic acid transporter.

doi:10.1111/j.1432-1033.1997.00187.x

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Article

Molecular cloning of the hamster CMP-sialic acid transporter.

European journal of biochemistry - 15 Aug 1997

Eckhardt M, Gerardy-Schahn R

Abstract excerpt

Chinese hamster ovary (CHO) glycosylation mutants of the Lec2 complementation group are unable to express sialylated glycoproteins and glycolipids due to a defect in the Golgi CMP-sialic acid transporter (CMP-Sia-Tr). Using an expression cloning strategy, we isolated a cDNA encoding the hamster CMP-Sia-Tr which complements the Lec2 phenotype. The deduced amino acid sequence of the cloned cDNA shows 95% identity...

Topics

Amino Acid Sequence
Animals
Base Sequence
CHO Cells
Carrier Proteins
Cloning, Molecular
Cricetinae
Cytidine Monophosphate
DNA Primers
Epitopes
Glycosylation
Golgi Apparatus
Humans
Membrane Proteins
Molecular Sequence Data
Molecular Structure
Mutation
N-Acetylneuraminic Acid

Source

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Identifiers

PMID: 9310377
DOI: 10.1111/j.1432-1033.1997.00187.x

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