Article
The functional and clinical significance of the Met-->Thr substitution in Kringle IV type 10 of apolipoprotein(a).
Thrombosis research - 1 May 1998
Prins J, van der Hoek Y Y, Biesheuvel T H, Leus F R, van Rijn H J, Kastelein J J
Abstract excerpt
Lipoprotein(a) [Lp(a)], an independent risk factor for the development of atherosclerosis, contains an apolipoprotein(a) [apo(a)] moiety covalently linked to a LDL moiety. Apo(a) is a glycoprotein homologous to plasminogen as it contains multiple repeats of a lysine binding domain resembling plas...
Topics
- Adult
- Alleles
- Amino Acid Substitution
- Apolipoproteins A
- Arteriosclerosis
- Case-Control Studies
- Cholesterol
- Female
- Humans
- Kringles
- Lipoprotein(a)
- Lysine
- Male
- Methionine
- Middle Aged
- Polymorphism, Genetic
- Threonine