Article
The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms.
Human molecular genetics - 1 Apr 1993
van der Hoek Y Y, Wittekoek M E, Beisiegel U, Kastelein J J, Koschinsky M L
Abstract excerpt
Elevated levels of plasma lipoprotein(a) [Lp(a)] have been correlated with the development of atherosclerosis in human populations. Apolipoprotein(a) [apo(a); the distinguishing protein component of Lp(a)] is characterized by multiple repeats of a sequence that closely resembles kringle IV of pla...
Topics
- Amino Acid Sequence
- Arteriosclerosis
- Base Sequence
- DNA
- Genetic Variation
- Humans
- Lipoprotein(a)
- Molecular Sequence Data
- Peptide Fragments
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid