Article
Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.
Biological chemistry - 1 Nov 2002
Caterer Nigel R, Graversen Jonas H, Jacobsen Christian, Moestrup Søren K, Sigurskjold Bent W, Etzerodt Michael, Thøgersen Hans C
Abstract excerpt
Lipoprotein(a) is composed of low density lipoprotein and apolipoprotein(a). Apolipoprotein(a) has evolved from plasminogen and contains 10 different plasminogen kringle 4 homologous domains [KIV(1-110)]. Previous studies indicated that lipoprotein(a) non-covalently binds the N-terminal region of lipoprotein B100 and the plasminogen kringle 4 binding plasma protein tetranectin. In this study recombinant KIV(2),...
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