Molecular cloning of the cDNA encoding the carboxy-terminal domain of chimpanzee apolipoprotein(a): an Asp57 --> Asn mutation in kringle IV-10 is associated with poor fibrin binding.

doi:10.1021/bi9721546

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Article

Molecular cloning of the cDNA encoding the carboxy-terminal domain of chimpanzee apolipoprotein(a): an Asp57 --> Asn mutation in kringle IV-10 is associated with poor fibrin binding.

Biochemistry - 19 May 1998

Chenivesse X, Huby T, Wickins J, Chapman J, Thillet J

Abstract excerpt

Insight into the structural features of human lipoprotein(a) [Lp(a)] which underlie its functional implication in fibrinolysis may be gained from comparative studies of apo(a). Indeed, cloning of rhesus monkey apo(a) has shown that a Trp72 --> Arg mutation in the lysine-binding site (LBS) of KIV-...

Topics

Amino Acid Substitution
Animals
Apolipoproteins
Apoprotein(a)
Asparagine
Aspartic Acid
Cloning, Molecular
DNA, Complementary
Female
Fibrin
Humans
Kringles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoprotein(a)

Macaca mulatta

Mutation

Pan troglodytes

Plasminogen

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 9585533
DOI: 10.1021/bi9721546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9585533-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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