Identification of mutations in human apolipoprotein(a) kringle 4-37 from the study of the DNA of peripheral blood lymphocytes: relevance to the role of lipoprotein(a) in atherothrombosis.

Abstract excerpt

Using a technique that amplifies the DNA region coding for kringle 4-37 of human apolipoprotein(a) we have identified 2 mutations, trp72-->arg and met66-->thr. The former was only present in 2 of the 100 subjects studied, was associated with a lysine-binding defective lipoprotein(a) [Lp(a)], low plasma levels of Lp(a), and no evidence of atherosclerotic cardiovascular disease (ASCVD). The other mutation was...

Topics

• Apolipoproteins A
• Arteriosclerosis
• DNA
• Humans
• Kringles
• Lipoprotein(a)
• Lymphocytes
• Lysine
• Mutation
• Polymorphism, Genetic
• Thrombosis