Apolipoprotein(a): structural and functional consequences of mutations in kringle type 10 (or kringle 4-37).

doi:10.1111/j.1399-0004.1994.tb04200.x

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Article

Apolipoprotein(a): structural and functional consequences of mutations in kringle type 10 (or kringle 4-37).

Clinical genetics - 1 Jul 1994

Scanu A M, Edelstein C

Abstract excerpt

The size polymorphism of Lp(a) is well recognized. It is now apparent that there is an additional polymorphism resulting from mutations occurring at the kringle level. One of these mutations involves a trp72 to arg substitution in apo(a) kringle type 10 and is attended by a defective binding of L...

Topics

Amino Acid Sequence
Animals
Apolipoproteins A
Humans
Kringles
Macaca mulatta
Molecular Sequence Data
Mutation
Polymorphism, Genetic
Protein Binding
Structure-Activity Relationship

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