Article
Loss of the G1-S control of cyclin A expression during tumoral progression of Chinese hamster lung fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1993
Barlat I, Fesquet D, Bréchot C, Henglein B, Dupuy d'Angeac A, Vié A, Blanchard J M
Abstract excerpt
The expression of cyclin A, one of the key regulators of cell cycle progression in association with cdc2/cdk2 protein kinases and which undergoes cyclic accumulation during the cell cycle, has been investigated in CCL39 Chinese hamster lung fibroblasts and in two transformed variants, A71 and 39Py. Whereas A71 (selected after tumor induction in nude mice) is subject to growth arrest (less than 5% of labeled...
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