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Article

Overexpression of cdk4/cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support.

FEBS letters - 14 Dec 2001

Katayama K, Dobashi Y, Kitagawa M, Kamekura S, Kawai M, Kadoya Y, Kameya T

Abstract excerpt

The induction of apoptosis by cell cycle regulator molecules under conditions optimal for exponential growth was examined in rat pheochromocytoma PC12 cells by overexpression of cyclins and cyclin-dependent kinases (cdks). By flow cytometry and by immunofluorescence, only cells overexpressing cdk4 or cyclin D1 underwent apoptosis, which was not associated with G1-arrest. Cdk4 kinase activity was significantly...

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Identifiers

PMID: 11749960
DOI: 10.1016/s0014-5793(01)03200-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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