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Article

Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite.

Archives of biochemistry and biophysics - 15 Feb 2003

Jiao Jing, Greendorfer Jessica S, Zhang Pei, Zinn Kurt R, Diglio Clement A, Thompson John A

Abstract excerpt

Mounting experimental evidence has suggested that the trophic environment of cells in culture is an important determinant of their vulnerability to the cytotoxic effects of reactive oxidants such as peroxynitrite (ONOO(-)). However, acidic fibroblast growth factor (FGF-1)-induced signaling renders some cells more sensitive and others resistant to the cytotoxic effects of ONOO(-). To determine whether...

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PMID: 12573278
DOI: 10.1016/s0003-9861(02)00681-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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