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Article

PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells.

Journal of cellular and molecular medicine - 1 Jan 2000

Perletti Gianpaolo, Marras Emanuela, Osti Daniela, Felici Lara, Zaro Sabrina, de Eguileor Magda

Abstract excerpt

We have previously demonstrated that the delta isoform of Protein Kinase C (PKCdelta) acts as a tumor suppressor in HCT116 human colon cancer cells, and that p21(waf1/cip1) is an essential downstream effector of PKCdelta. Our data suggested that p53 might also be involved in the suppression of the neoplastic phenotype induced by PKCdelta. Here we show that homozygous knockout of p53 renders the HCT116 cell line...

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Identifiers

PMID: 15601585
DOI: 10.1111/j.1582-4934.2004.tb00481.x
PMCID: PMC6740212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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