Sequence-specificity of Holliday junction resolution: identification of RuvC mutants defective in metal binding and target site recognition.

doi:10.1006/jmbi.1998.1934

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Article

Sequence-specificity of Holliday junction resolution: identification of RuvC mutants defective in metal binding and target site recognition.

Journal of molecular biology - 7 Aug 1998

Hagan N F, Vincent S D, Ingleston S M, Sharples G J, Bennett R J, West S C, Lloyd R G

Abstract excerpt

The RuvC protein of Escherichia coli resolves Holliday intermediates in recombination and DNA repair by a dual strand incision mechanism targeted to specific DNA sequences located symmetrically at the crossover. Two classes of amino acid substitutions are described that provide new insights into...

Topics

Amino Acid Sequence
Amino Acid Substitution
Bacterial Proteins
Base Sequence
Binding Sites
DNA Repair
DNA, Bacterial
Endodeoxyribonucleases
Escherichia coli
Escherichia coli Proteins
Hydroxyl Radical
Macromolecular Substances
Metals
Models, Molecular

Source

Open in PubMed

Identifiers

PMID: 9680472
DOI: 10.1006/jmbi.1998.1934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9680472-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Protein Conformation